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Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence

Choi, Jeong-Hwa, Yates, Zoe, Martin, Charlotte, Boyd, Lyndell, Ng, Xiaowei, Skinner, Virginia, Wai, Ron, Kim, Jeongseon, Woo, Hae, Veysey, Martin and Lucock, Mark (2015). Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence. Asian Pacific Journal of Cancer Prevention,16(10):4383-4386.

Document type: Journal Article
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IRMA ID 84377429xPUB60
Title Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence
Author Choi, Jeong-Hwa
Yates, Zoe
Martin, Charlotte
Boyd, Lyndell
Ng, Xiaowei
Skinner, Virginia
Wai, Ron
Kim, Jeongseon
Woo, Hae
Veysey, Martin
Lucock, Mark
Journal Name Asian Pacific Journal of Cancer Prevention
Publication Date 2015
Volume Number 16
Issue Number 10
ISSN 1513-7368   (check CDU catalogue  open catalogue search in new window)
Scopus ID 2-s2.0-84930721733
Start Page 4383
End Page 4386
Total Pages 4
Place of Publication Thailand
Publisher Asian Pacific Organization for Cancer Prevention
HERDC Category C1 - Journal Article (DIISR)
Abstract Background:
The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. However, little is known on C1561T-GCPII as a risk factor for colorectal cancer. Therefore, this study examined whether C1561T-GCPII influences folate metabolism and adenomatous polyp occurrence. Materials and Methods: 164 controls and 38 adenomatous polyp cases were analysed to determine blood folate and plasma homocysteine (Hcy) level, dietary intake of natural methylfolate, synthetic pteroylglutamic acid (PteGlu), vitamin C and C1561T-GCPII genotype.

Results:
 
In controls and cases, 7.3 and 18.4 percent of subjects respectively, were found to have the CT genotype, increasing the risk for adenomatous polyp occurrence 2.86 times (95% CI:1.37-8.0, p=0.035). Total dietary folate, methylfolate and PteGlu intake and the level of erythrocyte folate and plasma Hcy did not predict the occurrence of an adenomatous polyp. However, dietary natural vitamin C intake was associated with adenomatous polyp risk within C1561T-GCPII CT genotype subjects (p=0.037).

Conclusions:
The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates.
Keywords Adenomatous polyp
Colorectal cancer
Folate
GCPII
Polymorphism
Vitamin C
DOI http://dx.doi.org/10.7314/APJCP.2015.16.10.4383   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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