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Coinfection with Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis: a crosssectional analysis of positivity and risk factors in remote Australian Aboriginal communities

Guy, Rebecca, Ward, James, Wand, Handan, Rumbold, Alice R., Garton, Linda, Hengel, Belinda, Silver, Bronwyn J., Taylor-Thomson, Debbie M., Knox, Janet, McGregor, Skye, Dyda, Amalie, Fairley, Christopher, Maher, Lisa, Donovan, Basil, Kaldor, John and STRIVE Investigator Group (2015). Coinfection with Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis: a crosssectional analysis of positivity and risk factors in remote Australian Aboriginal communities. Sexually Transmitted Infections,91(3):201-206.

Document type: Journal Article
Citation counts: Altmetric Score Altmetric Score is 6
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IRMA ID 84473293xPUB116
Title Coinfection with Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis: a crosssectional analysis of positivity and risk factors in remote Australian Aboriginal communities
Author Guy, Rebecca
Ward, James
Wand, Handan
Rumbold, Alice R.
Garton, Linda
Hengel, Belinda
Silver, Bronwyn J.
Taylor-Thomson, Debbie M.
Knox, Janet
McGregor, Skye
Dyda, Amalie
Fairley, Christopher
Maher, Lisa
Donovan, Basil
Kaldor, John
STRIVE Investigator Group
Journal Name Sexually Transmitted Infections
Publication Date 2015
Volume Number 91
Issue Number 3
ISSN 1368-4973   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84928986657
Start Page 201
End Page 206
Total Pages 6
Place of Publication United Kingdom
Publisher B M J Group
Field of Research MEDICAL AND HEALTH SCIENCES
HERDC Category C1 - Journal Article (DIISR)
Abstract Objectives
To determine the co-occurrence and epidemiological relationships of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) in a high-prevalence setting in Australia.

Methods
In the context of a cluster randomised trial in 68 remote Aboriginal communities, we obtained laboratory reports on simultaneous testing for CT, NG and TV by nucleic acid amplification tests in individuals aged ≥16 years and examined relationships between age and sex and the coinfection positivity. ORs were used to determine which infections were more likely to co-occur by demographic category.

Results
Of 13 480 patients (median age: 30 years; men: 37%) tested for all three infections during the study period, 33.3% of women and 21.3% of men had at least one of them, highest in patients aged 16–19 years (48.9% in women, 33.4% in men). The most frequent combination was CT/NG (2.0% of women, 4.1% of men), and 1.8% of women and 0.5% of men had all three. In all co-combinations, coinfection positivity was highest in patients aged 16–19 years. CT and NG were highly predictive of each other's presence, and TV was associated with each of the other two infections, but much more so with NG than CT, and its associations were much stronger in women than in men.

Conclusions
In this remote high-prevalence area, nearly half the patients aged 16–19 years had one or more sexually transmitted infections. CT and NG were more common dual infections. TV was more strongly associated with NG coinfections than with CT. These findings confirm the need for increased simultaneous screening for CT, NG and TV, and enhanced control strategies.
DOI http://dx.doi.org/10.1136/sextrans-2014-051535   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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