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In Vitro Analysis of the Effect of In-Line 1.2 Micron Filters on Two Formulations of Propofol (2,6-Diisopropyl Phenol)

Kennedy, Ross A., Kennedy, Michelle L., Morrissey, Hana and Ball, Patrick A. (2015). In Vitro Analysis of the Effect of In-Line 1.2 Micron Filters on Two Formulations of Propofol (2,6-Diisopropyl Phenol). PDA Journal of Pharmaceutical Science and Technology,69(2):297-306.

Document type: Journal Article
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IRMA ID 84377429xPUB46
Title In Vitro Analysis of the Effect of In-Line 1.2 Micron Filters on Two Formulations of Propofol (2,6-Diisopropyl Phenol)
Author Kennedy, Ross A.
Kennedy, Michelle L.
Morrissey, Hana
Ball, Patrick A.
Journal Name PDA Journal of Pharmaceutical Science and Technology
Publication Date 2015
Volume Number 69
Issue Number 2
ISSN 1079-7440   (check CDU catalogue  open catalogue search in new window)
Start Page 297
End Page 306
Total Pages 10
Place of Publication United States of America
Publisher Parenteral Drug Association
HERDC Category C1 - Journal Article (DIISR)
Abstract Recent evidence has shown improved outcomes in pediatric intensive care units with the intensive use of intravenous in-line filtration. This has caused resurgence in interest in filter use but has raised questions in relation to emulsion-based formulations such as propofol. Our objective was to test two propofol products, Diprivan® and Fresofol®, with the Pall Lipipor® TNA and Lipipor NLF intravenous in-line filters and to assay the content before and after filtration under typical infusion conditions. The propofol emulsions were delivered from a 50 mL syringe through an extension set and into either a Lipipor TNA (50 mL/h–1) or Lipipor NLF (20 mL/h–1) filter. Samples were taken at regular intervals and assayed using a high-performance liquid chromatography method before and after filtration. No evidence was found of a significant concentration change during passage of either product through either model of filter. Propofol from two products was found to pass through two different types of Pall 1.2 μm intravenous in-line filters. There was no significant change in concentration before and after filtration under typical conditions of administration. In conclusion, administration of these products through these models of in-line filter would be safe and effective.
Keywords Propofol
Emulsions
In-line filtration
Pediatric
Intensive care units
Intravenous
DOI http://dx.doi.org/10.5731/pdajpst.2015.01033   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Tue, 26 Jul 2016, 13:00:41 CST