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Neurotropic Threat Characterization of Burkholderia pseudomallei Strains

Morris, Jodie, Fane, Anne, Rush, Catherine, Govan, Brenda, Mayo, Mark J., Currie, Bart J. and Ketheesan, Natkunam (2015). Neurotropic Threat Characterization of Burkholderia pseudomallei Strains. Emerging Infectious Diseases,21(1):58-63.

Document type: Journal Article
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IRMA ID 75039815xPUB675
Title Neurotropic Threat Characterization of Burkholderia pseudomallei Strains
Author Morris, Jodie
Fane, Anne
Rush, Catherine
Govan, Brenda
Mayo, Mark J.
Currie, Bart J.
Ketheesan, Natkunam
Journal Name Emerging Infectious Diseases
Publication Date 2015
Volume Number 21
Issue Number 1
ISSN 1080-6040   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-84919607840
Start Page 58
End Page 63
Total Pages 6
Place of Publication United States of America
Publisher U.S. Department of Health and Human Services * Centers for Disease Control and Prevention
HERDC Category C1 - Journal Article (DIISR)
Abstract The death rate for neurologic melioidosis is high. Whether certain Burkholderia pseudomallei strains are more likely than other strains to cause central nervous system infection and whether route of infection influences the neurotropic threat remain unclear. Therefore, we compared the virulence and dissemination of Australian clinical isolates collected during October 1989–October 2012 from patients with neurologic and nonneurologic melioidosis after intranasal and subcutaneous infection of mice in an experimental model. We did not observe neurotropism as a unique characteristic of isolates from patients with neurologic melioidosis. Rather, a distinct subset of B. pseudomallei strains appear to have heightened pathogenic potential for rapid dissemination to multiple tissues, including the central nervous system, irrespective of the infection route. This finding has valuable public health ramifications for initiating appropriate and timely therapy after exposure to systemically invasive B. pseudomallei strains. Increasing understanding of B. pseudomallei pathology and its influencing factors will further reduce illness and death from this disease.
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