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Immunohistochemical expression levels of p53 and eIF4E markers in histologically negative surgical margins, and their association with the clinical outcome of patients with head and neck squamous cell carcinoma

Singh, Jagtar, Jayaraj, Ramamoorthi, Baxi, Siddhartha, Mileva, Mariana, Skinner, John, Dhand, Navneet K. and Thomas, Mahiban (2016). Immunohistochemical expression levels of p53 and eIF4E markers in histologically negative surgical margins, and their association with the clinical outcome of patients with head and neck squamous cell carcinoma. Molecular and Clinical Oncology,4(2):166-172.

Document type: Journal Article
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Title Immunohistochemical expression levels of p53 and eIF4E markers in histologically negative surgical margins, and their association with the clinical outcome of patients with head and neck squamous cell carcinoma
Author Singh, Jagtar
Jayaraj, Ramamoorthi
Baxi, Siddhartha
Mileva, Mariana
Skinner, John
Dhand, Navneet K.
Thomas, Mahiban
Journal Name Molecular and Clinical Oncology
Publication Date 2016
Volume Number 4
Issue Number 2
ISSN 2049-9450   (check CDU catalogue  open catalogue search in new window)
eISSN 2049-9469
Start Page 166
End Page 172
Total Pages 7
Place of Publication Greece
Publisher Spandidos Publications
Language English
Field of Research MEDICAL AND HEALTH SCIENCES
111202 - Cancer Diagnosis
Abstract Molecular markers can be used to identify residual cancer at the surgical margins of head and neck squamous cell carcinoma (HNSCC) and assist in evaluating the complete resection of the tumour. The purpose of the present study was to investigate the expression levels of prognostic molecular markers at the histological tumour free surgical margins. In the present clinical retrospective study, 24/48 patients were selected with negative surgical margins for further analysis with immunohistochemical staining. Contingency tables and Fisher's exact tests were used to investigate the association between the expression levels of p53 and eukaryotic translation imitation factor 4E (eIF4E) with the clinical outcomes for patients with HNSCC. The expression levels of p53 and eIF4E were 54.2 and 87.5%, respectively, in the surgical margins of patients with HNSCC. A total of 3/7 patients with recurrent cancer (42.8%) were identified with p53‑positive margins, and 6 (85.7%) patients exhibited recurrence with eIF4e‑positive margins. No statistically significant differences were identified for the recurrence risk between the overexpression of p53 and eIF4E in the surgical margins (P=0.88 and P=0.99, respectively). The eIF4E marker appears to be a more marked prognosticator compared with p53, as overexpression of eIF4E was identified in the margins of 6/7 patients with local recurrence.
Keywords eukaryotic translation imitation factor 4E
immunohistochemistry
molecular markers
p53
recurrence
overall survival
DOI http://dx.doi.org/10.3892/mco.2015.689   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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Created: Thu, 15 Jun 2017, 10:56:42 CST by Ramamoorthi Jayaraj