Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults

Boutlis, Craig S., Gowda, D. Channe, Naik, Ramachandra S., Maguire, Graeme P., Mgone, Charles S., Bockarie, Moses J., Lagog, Moses, Ibam, Erwin, Lorry, Kerry and Anstey, Nicholas M. (2002). Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults. Infection and Immunity,70(9):5052-5057.

Document type: Journal Article
Citation counts:
Google Scholar Search Google Scholar
Attached Files (Some files may be inaccessible until you login with your CDU eSpace credentials)
Name Description MIMEType Size Downloads
Download this reading Boutlis_634.pdf Published version application/pdf 168.75KB 97
Reading the attached file works best in Firefox, Chrome and IE 9 or later.

Title Antibodies to Plasmodium falciparum glycosylphosphatidylinositols: inverse association with tolerance of parasitemia in Papua New Guinean children and adults
Author Boutlis, Craig S.
Gowda, D. Channe
Naik, Ramachandra S.
Maguire, Graeme P.
Mgone, Charles S.
Bockarie, Moses J.
Lagog, Moses
Ibam, Erwin
Lorry, Kerry
Anstey, Nicholas M.
Journal Name Infection and Immunity
Publication Date 2002
Volume Number 70
Issue Number 9
ISSN 0019-9567   (check CDU catalogue open catalogue search in new window)
Start Page 5052
End Page 5057
Total Pages 6
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Individuals living in regions of intense malaria transmission exhibit natural immunity that facilitates persistence of parasitemia at controlled densities for much of the time without symptoms. This aspect of immunity has been referred to as malarial tolerance and is thought to partly involve inhibition of the chain of events initiated by a parasite toxin(s) that may otherwise result in cytokine release and symptoms such as fever. Antibodies to the candidate Plasmodium falciparum glycosylphosphatidylinositol (GPI) toxin have been viewed as likely mediators of such tolerance. In this study, the relationship between antibodies to P. falciparum GPIs, age, and parasitemia was determined in asymptomatic children and adults living in Madang, Papua New Guinea. The prevalence and intensity of antibody responses increased with age and were lowest in children I to 4 years old with the highest-density parasitemias. In children of this age group who were tolerant of parasitemia during the study, only 8.3% had detectable immunoglobulin G (IgG) and nonce had IgM antibodies to GPI. This suggests that anti-GPI antibodies are unlikely to be the sole mediator of malarial tolerance, especially in children younger than 5 years. Following antimalarial treatment, clearance of parasitemia led to a fall in anti-GPI IgG response in children and adolescents within 6 weeks. As anti-GPI antibodies potentially play a role in protecting against disease progression, our results caution against the treatment of asymptomatic parasitemia and suggest that generation of a sustained antibody response in children poses a challenge to novel antitoxic vaccination strategies.
Keywords asymptomatic malaria infections
synthase type-2 expression
vascular endothelial-cells
nitric-oxide
signal-transduction
toxin
transmission
vivax
age
epidemiology
adult
antibodies
children
falciparum
DOI http://dx.doi.org/10.1128/IAI.70.9.5052-5057.2002   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society for Microbiology


© copyright

Every reasonable effort has been made to ensure that permission has been obtained for items included in CDU eSpace. If you believe that your rights have been infringed by this repository, please contact digitisation@cdu.edu.au.

 
Versions
Version Filter Type
Access Statistics: 68 Abstract Views, 98 File Downloads  -  Detailed Statistics
Created: Fri, 12 Sep 2008, 08:35:25 CST by Administrator