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Superantigen genes in group A streptococcal isolates and their relationship with emm types

Commons, R., Rogers, S., Gooding, T., Danchin, M., Carapetis, Jonathan, Robins-Browne, R. and Curtis, N. (2008). Superantigen genes in group A streptococcal isolates and their relationship with emm types. Journal of Medical Microbiology,57(10):1238-1246.

Document type: Journal Article

ISI LOC 000259950400009
IRMA ID 10414xPUB61
Title Superantigen genes in group A streptococcal isolates and their relationship with emm types
Author Commons, R.
Rogers, S.
Gooding, T.
Danchin, M.
Carapetis, Jonathan
Robins-Browne, R.
Curtis, N.
Journal Name Journal of Medical Microbiology
Publication Date 2008
Volume Number 57
Issue Number 10
ISSN 0022-2615   (check CDU catalogue open catalogue search in new window)
Start Page 1238
End Page 1246
Total Pages 9
Place of Publication UK
Publisher Society for General Microbiology
Field of Research 1108 - Medical Microbiology
0707 - Veterinary Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Superantigens are important virulence factors in the pathogenesis of invasive disease caused by group A streptococcus (GAS). There has been a recent re-emergence of this disease worldwide. A number of novel superantigens have been described recently. This study investigated 107 isolates of GAS for possession of each of the 11 currently known superantigen genes to determine the prevalence, co-occurrence and genetic restriction amongst different emm types of GAS. The results were compared with those in previously published studies. Superantigen genes were not randomly distributed amongst GAS isolates. Certain combinations of superantigen genes were more common and the majority of emm types showed restricted superantigen profiles. This is the first prevalence study of GAS isolates to include the complete range of known superantigen genes and their restriction amongst emm types. This study contributes to the understanding of the relationship between superantigen genes and emm types, and highlights the importance of comprehensive studies in different populations.
Keywords GAS
group A streptococcus
DOI http://dx.doi.org/10.1099/jmm.0.2008/001156-0   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Description for Link Link to Article
URL http://jmm.sgmjournals.org/cgi/reprint/57/10/1238?maxtoshow=&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=57&firstpage=1238&resourcetype=HWCIT
 
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Created: Wed, 15 Apr 2009, 13:06:49 CST by Sarena Wegener