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Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population

Leach, Amanda J., Morris, Peter S., Mackenzie, Grant A., McDonnell, Joseph, Balloch, Anne, Carapetis, Jonathan R. and Tang, Mimi (2008). Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population. Vaccine,26(31):3885-3891.

Document type: Journal Article

IRMA ID 10016xPUB12
Title Immunogenicity for 16 serotypes of a unique schedule of pneumococcal vaccines in a high-risk population
Author Leach, Amanda J.
Morris, Peter S.
Mackenzie, Grant A.
McDonnell, Joseph
Balloch, Anne
Carapetis, Jonathan R.
Tang, Mimi
Journal Name Vaccine
Publication Date 2008
Volume Number 26
Issue Number 31
ISSN 0264-410X   (check CDU catalogue  open catalogue search in new window)
Start Page 3885
End Page 3891
Total Pages 7
Place of Publication UK
Publisher Elsevier
Field of Research 0699 - Other Biological Sciences
0799 - Other Agricultural and Veterinary Sciences
1107 - Immunology
HERDC Category C1 - Journal Article (DEST)
Abstract Background
A unique schedule of 7-valent pneumococcal conjugate vaccine (7PCV) at 2, 4 and 6 months of age and 23-valent pneumococcal polysaccharide vaccine (23PPV) at 18 months commenced for Australian Aboriginal infants in 2001.

Methods

Anti-capsular IgG concentrations in vaccinated and non-vaccinated (historic control) infants were determined (blinded) by (22F absorbed) ELISA.

Results

One month after dose 3 of 7PCV, geometric mean concentrations (GMCs) were >1.95 μg/ml and at least 89% of infants had IgG >0.35 μg/ml to all 7PCV serotypes. One month post-23PPV, IgG to 7PCV serotypes was >0.35 μg/ml for more than 96% infants (>1.3 μg/ml for at least 70%), and IgG to non-7PCV serotypes was >0.35 μg/ml for more than 50% infants (including serotype 6A, but not 12F (17%) or 19A (44%).

Conclusion

7PCV and 23PPV are immunogenic in this population.
Keywords Immunogenicity
16 Serotypes
Pneumococcal vaccines
High-risk population
DOI http://dx.doi.org/10.1016/j.vaccine.2008.05.012   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Thu, 16 Apr 2009, 15:39:01 CST by Sarena Wegener