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L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis

Ralph, A., Kelly, P. and Anstey, Nicholas M. (2008). L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis. Trends in Microbiology,16(7):336-344.

Document type: Journal Article

IRMA ID 10002xPUB49
Title L-arginine and vitamin D: novel adjunctive immunotherapies in tuberculosis
Author Ralph, A.
Kelly, P.
Anstey, Nicholas M.
Journal Name Trends in Microbiology
Publication Date 2008
Volume Number 16
Issue Number 7
ISSN 0966-842X   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-46049098541
Start Page 336
End Page 344
Total Pages 9
Place of Publication UK
Publisher Elsevier, Trends Journals
Field of Research 0605 - Microbiology
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Worsening drug resistance and the need for prolonged treatment in tuberculosis (TB) require innovative solutions including investigation of inexpensive, safe adjunctive immunotherapies. L-arginine, the precursor of nitric oxide, and vitamin D recently have elucidated mycobactericidal and immunomodulatory actions against TB and are deficient in people with TB. We review the potential of these agents as adjunctive TB immunotherapies and explore how comparative clinical trials might help clarify their relative importance in the human TB immune response. By enhancing mycobacterial killing in macrophages, L-arginine and vitamin D might have the potential to enable shorter duration of treatment, reduced infectivity and improved response in drug-resistant TB.
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Created: Tue, 28 Apr 2009, 11:31:59 CST by Sarena Wegener