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Genetic diversity of Burkholderia pseudomallei isolates in Australia

Cheng, Allen C., Ward, Linda, Godoy, Daniel, Norton, Robert, Mayo, Mark, Gal, Daniel, Spratt, Brian G. and Currie, Bart J. (2008). Genetic diversity of Burkholderia pseudomallei isolates in Australia. Journal of Clinical Microbiology,46(1):249-254.

Document type: Journal Article
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IRMA ID 10103xPUB17
Title Genetic diversity of Burkholderia pseudomallei isolates in Australia
Author Cheng, Allen C.
Ward, Linda
Godoy, Daniel
Norton, Robert
Mayo, Mark
Gal, Daniel
Spratt, Brian G.
Currie, Bart J.
Journal Name Journal of Clinical Microbiology
Publication Date 2008
Volume Number 46
Issue Number 1
ISSN 0095-1137   (check CDU catalogue open catalogue search in new window)
Start Page 249
End Page 254
Total Pages 6
Place of Publication Washington, United States
Publisher American Society for Microbiology
Field of Research 0605 - Microbiology
0707 - Veterinary Sciences
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Melioidosis is caused by the gram-negative saprophytic bacterium Burkholderia pseudomallei, which is endemic to southeast Asia and northern Australia. We have previously found evidence of geographic localization of strains based on multilocus sequence typing (MLST). In this study, we examined the diversity of 277 isolates from northern Australia, which were resolved into 159 different sequence types. No sequence types were common to both Queensland and the Northern Territory, and there was significant differentiation between the alleles present in the two regions. The considerable diversity in sequence types contrasts with the limited diversity of alleles at MLST loci, supporting previous work suggesting a high rate of recombination relative to mutation in B. pseudomallei, where new sequence types are primarily generated by reassortment of existing alleles.
Keywords Burkholderia pseudomallei
DOI   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society for Microbiology

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