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Simplified antimalarial therapeutic monitoring: using the day-7 drug level?

White, N, Stepniewska, K., Barnes, K, Price, Ric and Simpson, J (2008). Simplified antimalarial therapeutic monitoring: using the day-7 drug level?. Trends in Parasitology,24(4):159-163.

Document type: Journal Article

IRMA ID 10202xPUB26
Title Simplified antimalarial therapeutic monitoring: using the day-7 drug level?
Author White, N
Stepniewska, K.
Barnes, K
Price, Ric
Simpson, J
Journal Name Trends in Parasitology
Publication Date 2008
Volume Number 24
Issue Number 4
ISSN 1471-4922   (check CDU catalogue open catalogue search in new window)
Start Page 159
End Page 163
Total Pages 5
Place of Publication UK
Publisher Elsevier Ltd.
Field of Research 0605 - Microbiology
0707 - Veterinary Sciences
1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract The blood concentration profiles of most antimalarial drugs vary considerably between patients. The interpretation of antimalarial drug trials evaluating efficacy and effectiveness would be improved considerably if the exposure of the infecting parasite population to the antimalarial drug treatment could be measured. Artemisinin combination treatments are now recommended as first-line drugs for the treatment of falciparum malaria. Measurement of the blood, serum or plasma concentration of the slowly eliminated partner antimalarial drug on day 7 of follow-up is simpler and might be a better determinant of therapeutic response than the area under the concentration–time curve. Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials.
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Created: Wed, 29 Apr 2009, 12:43:41 CST by Sarena Wegener