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Impact of dyslipidaemia on arterial structure and function in urban Indigenous Australians

Maple-Brown, Louise J., Cunningham, Joan, Barry, Robert E., Leylsey, Loyla, O’Rourke, Michael F., Celermajer, David S. and O'Dea, Kerin (2009). Impact of dyslipidaemia on arterial structure and function in urban Indigenous Australians. Atherosclerosis,202(1):248-254.

Document type: Journal Article

IRMA ID 10426xPUB10
Title Impact of dyslipidaemia on arterial structure and function in urban Indigenous Australians
Author Maple-Brown, Louise J.
Cunningham, Joan
Barry, Robert E.
Leylsey, Loyla
O’Rourke, Michael F.
Celermajer, David S.
O'Dea, Kerin
Journal Name Atherosclerosis
Publication Date 2009
Volume Number 202
Issue Number 1
ISSN 0021-9150   (check CDU catalogue  open catalogue search in new window)
Start Page 248
End Page 254
Total Pages 7
Place of Publication Ireland
Publisher Elsevier Ireland
Field of Research 1103 - Clinical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Background
Premature cardiovascular disease (CDV) is highly prevalent in urban Indigenous Australians. We studied arterial structure and function in 144 volunteers aged 15–66 years to assess the role of dyslipidaemia and other traditional vascular risk factors on cardiovascular risk in young and older urban Indigenous Australians.

Methods

We assessed carotid intima-media thickness (CIMT) by high-resolution B-mode ultrasound imaging of the common carotid artery and peripheral wave reflection using applanation tonometry to obtain the aortic augmentation index (AI) in Indigenous Australian participants of the Darwin Region Urban Indigenous Diabetes (DRUID) study.

Results

Participants aged 15–24 years demonstrated fewer cardiovascular risk factors than the older group (25–66 years) and predictors of CIMT and AI differed between younger and older groups. CIMT was higher in the older group (0.67 mm vs. 0.61 mm, p = 0.004) and in those with diabetes (0.81 mm vs. 0.67 mm, p < 0.001). AI was higher in the older group (24% vs. 0%, p < 0.001), but was not affected by diabetes status. On multivariate regression analysis, low HDL-cholesterol was the only independent predictor of CIMT in the younger group; triglycerides, heart rate (inverse) and height (inverse) were independent predictors of AI in the same group.

Conclusion

Dyslipidaemia (low HDL-cholesterol or elevated triglycerides) is independently associated with non-invasive measures of cardiovascular disease in a relatively healthy and young subgroup of this high-risk population. We propose that triglycerides and low HDL-cholesterol may represent the most useful commonly measured clinical indicators of cardiovascular risk in young, urban Indigenous Australians.
Keywords Arterial stiffness
Central obesity
Augmentation index
carotid intima-media thickness
Indigenous Australians
Dyslipidaemia
DOI http://dx.doi.org/10.1016/j.atherosclerosis.2008.03.017   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 29 Apr 2009, 12:49:02 CST by Sarena Wegener