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Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance

Mounsey, Kate E., Holt, Deborah C., Mccarthy, J., Currie, Bart J. and Walton, Shelley F. (2008). Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance. Future Microbiology,3(1):57-66.

Document type: Journal Article

IRMA ID 10245xPUB3
Title Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance
Author Mounsey, Kate E.
Holt, Deborah C.
Mccarthy, J.
Currie, Bart J.
Walton, Shelley F.
Journal Name Future Microbiology
Publication Date 2008
Volume Number 3
Issue Number 1
ISSN 1746-0913   (check CDU catalogue open catalogue search in new window)
Start Page 57
End Page 66
Total Pages 10
Place of Publication UK
Publisher Future Medicine Ltd.
Field of Research 1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Limited effective treatments, coupled with recent observations of emerging drug resistance to oral ivermectin and 5% permethrin, raise concerns regarding the future control of scabies, especially in severe cases and in endemic areas where repeated community treatment programs are in place. There is consequently an urgent need to define molecular mechanisms of drug resistance in scabies mites and to develop and assess alternative therapeutic options, such as tea tree oil, in the event of increasing treatment failure. Molecular studies on scabies mites have, until recently, been restricted; however, recent advances are providing new insights into scabies mite biology and genetic mechanisms underlying drug resistance. These may assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance.
Keywords drug resistance
ivermectin
permethrin
scabies
treatments
DOI http://dx.doi.org/10.2217/17460913.3.1.57   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 29 Apr 2009, 14:06:01 CST by Sarena Wegener