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A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial

Chang, Anne B., Clark, Ronald, Sloots, Theo P., Stone, David G., Petsky, Helen L., Thearle, Donna, Champion, Anita A., Wheeler, Coralie and Acworth, Jason P. (2008). A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial. Medical Journal of Australia,189(6):306-310.

Document type: Journal Article
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IRMA ID 10491xPUB102
Title A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial
Author Chang, Anne B.
Clark, Ronald
Sloots, Theo P.
Stone, David G.
Petsky, Helen L.
Thearle, Donna
Champion, Anita A.
Wheeler, Coralie
Acworth, Jason P.
Journal Name Medical Journal of Australia
Publication Date 2008
Volume Number 189
Issue Number 6
ISSN 0025-729X   (check CDU catalogue open catalogue search in new window)
Start Page 306
End Page 310
Total Pages 5
Place of Publication Australia
Publisher Australasian Medical Publishing Company
Field of Research 1117 - Public Health and Health Services
HERDC Category C1 - Journal Article (DEST)
Abstract Objective:
To determine whether a 5-day course of oral prednisolone is superior to a 3-day course in reducing the 2-week morbidity of children with asthma exacerbations who are not hospitalised.

Design, setting and participants:
Double-blind randomised controlled trial of asthma outcomes following a 5-day course of oral prednisolone (1 mg/kg) compared with a 3-day course of prednisolone plus placebo for 2 days. Participants were children aged 2–15 years who presented to the emergency departments of three Queensland hospitals between March 2004 and February 2007 with an acute exacerbation of asthma, but were not hospitalised. Sample size was defined a priori for a study power of 90%.

Main outcome measures:
Difference in proportion of children who were symptom-free at Day 7, as measured by intention-to-treat (ITT) and per-protocol analysis; quality of life (QOL) on Days 7 and 14.

Results:
201 children were enrolled, and there was an 82% completion rate. There was no difference between groups in the proportion of children who were symptom-free (observed difference, 0.04 [95% CI, − 0.09 to 0.18] by ITT analysis; 0.04 [95% CI, − 0.17 to 0.09] by per-protocol analysis). There was also no difference between groups in QOL (P = 0.42). The difference between groups for the primary outcome was within the equivalence range calculated post priori.

Conclusion:
A 5-day course of oral prednisolone confers no advantage over a 3-day course for children with asthma exacerbations who are not hospitalised.

Trial registration:
Australian Clinical Trials Registry ACTRN012605000305628.
Description for Link Link to published version
URL https://www.mja.com.au/journal/2008/189/6/5-versus-3-day-course-oral-corticosteroids-children-asthma-exacerbations-who-are


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