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Molecular insights into xenobiotic disposition in Australian Marsupials

El-Merhibi, A., Ngo, S., Jones, B., Milic, Natalie, Mckinnon, R. and Stupans, I. (2008). Molecular insights into xenobiotic disposition in Australian Marsupials. Australasian Journal of Ecotoxicology,13(3):53-64.

Document type: Journal Article

IRMA ID 79763552xPUB18
Title Molecular insights into xenobiotic disposition in Australian Marsupials
Author El-Merhibi, A.
Ngo, S.
Jones, B.
Milic, Natalie
Mckinnon, R.
Stupans, I.
Journal Name Australasian Journal of Ecotoxicology
Publication Date 2008
Volume Number 13
Issue Number 3
ISSN 1323-3475   (check CDU catalogue open catalogue search in new window)
Start Page 53
End Page 64
Total Pages 12
Place of Publication Sydney
Publisher Australiasian Society for Ecotoxicology
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract During the past two decades, studies of xenobiotic detoxification by molecular biology in diverse organisms have identified many novel environmental adaptions, providing valuable insight into habitat, dietary preferences and general physiology. While xenbiotic detoxification has been extensively studied in eutherian mammals, metabolic data concerning detoxification in Australian marsupials are limited, particularly at the molecular level of the enzymes involved. At present Australia relies heavily on overseas data to determine the possible outcomes of xenbiotic exposure in Australian native fauna. Unlike eutherian mammals, many marsupial herbivores ingest and absorb large amounts of dietary Eucalyptus terpenes. Such quantities would be toxic, even potentially fatal, to human and many other mammalian species. Specialist Eucalyptus herbivores, such as koalas and brushtail possums, have been hypothesised to utilise highly efficient enzyme systems to metabolise terpenes to non-toxic substances that can be readily excreted in the urine. Enzymes that carry out the biotransformation of Eucalyptus terpenes have been pertially identified to be the cytochromes P450 (CYP). The aim of this review is to provide a summary of work being undertaken over several years in our laboratories that has provided unique insights into marsupial biology. The focuses of this study are phase I and phase II metabolisms in these unique animals, the multiplicity of metabolising enzymes/pathways involved, induction/inhibition of CYPs/other enzymes by dietary Eucalyptus terpenes and to update current knowledge of xenobiotic metabolism in Australian marsupials. The important role of marsupial genome studies in identifying evolutionary relationships and functions for mammalian genes as well as in conservation, ecology and pest management of marsupial species is also briefly highlighted.
 
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Created: Thu, 07 May 2009, 10:43:45 CST by Sarena Wegener