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Strategies to reduce mortality from bacterial sepsis in adults in developing countries

Cheng, Allen C., West, T. Eoin, Limmathurotsakul, Direk and Peacock, Sharon J. (2008). Strategies to reduce mortality from bacterial sepsis in adults in developing countries. PloS Medicine,5(8 - Article No. e175).

Document type: Journal Article
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Title Strategies to reduce mortality from bacterial sepsis in adults in developing countries
Author Cheng, Allen C.
West, T. Eoin
Limmathurotsakul, Direk
Peacock, Sharon J.
Journal Name PloS Medicine
Publication Date 2008
Volume Number 5
Issue Number 8 - Article No. e175
ISSN 1549-1277   (check CDU catalogue open catalogue search in new window)
Total Pages 7
Place of Publication San Francisco, CA, United States
Publisher Public Library of Science
Field of Research 1108 - Medical Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Sepsis is a progressive injurious process resulting from a systemic inflammatory response to infection [1]. In developed countries, sepsis is an important cause of mortality: in the United States alone, up to 750,000 people annually suffer from severe sepsis—mostly bacterial in aetiology—of whom 29% may die [2,3]. Unfortunately, data on bacterial sepsis in developing countries are notably lacking, particularly in adults. Estimates of the burden of lower respiratory tract infections, meningitis, and “other infections”, of which a significant proportion are associated with severe sepsis, show that the majority of deaths and disability-adjusted life years lost occur in low-income countries (Figure 1) [4]. Additionally, severe sepsis is likely to complicate a varying proportion of cases of malaria, HIV/AIDS, diabetes, maternal conditions, and cancer deaths globally.
Keywords bacterial sepsis
developing countries
DOI http://dx.doi.org/10.1371/journal.pmed.0050175   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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