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Systematic review of trends in prophylaxis of corticosteroid-induced osteoporosis: the need for standard audit guidelines

Duyvendak, M, Naunton, M, van Roon, EN, Bruyn, GAW and Brouwers, JRBJ (2008). Systematic review of trends in prophylaxis of corticosteroid-induced osteoporosis: the need for standard audit guidelines. Osteoporosis International,19(10):1379-1394.

Document type: Journal Article
Citation counts: Scopus Citation Count Cited 5 times in Scopus Article | Citations

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Title Systematic review of trends in prophylaxis of corticosteroid-induced osteoporosis: the need for standard audit guidelines
Author Duyvendak, M
Naunton, M
van Roon, EN
Bruyn, GAW
Brouwers, JRBJ
Journal Name Osteoporosis International
Publication Date 2008
Volume Number 19
Issue Number 10
ISSN 1433-2965   (check CDU catalogue open catalogue search in new window)
Scopus ID 2-s2.0-51249090119
Start Page 1379
End Page 1394
Total Pages 16
Place of Publication London
Publisher Springer Publishing
Field of Research 1103 - Clinical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Summary: Corticosteroid-induced osteoporosis (CIOP) is currently undertreated. Systematic review of the literature revealed that the percentage of patients treated adequately is dependent on study quality. Therefore, it remains unknown whether adherence to the guidelines is really so poor. Five major quality criteria provide the standard for future studies on this scope.

Introduction: It has recently been stated that the degree of prophylaxis of corticosteroid-induced osteoporosis (CIOP) is low and effort should be put into determining reasons for non-prescribing of preventive agents. The aim of this study was to identify: how many studies adequately audit the prevalent guideline; the longitudinal trends in prevention of CIOP; which patient groups appear to be most undertreated; and which intervention strategies are effective.

Methods: We performed a comprehensive search of MEDLINE and systematically recorded the outcomes and quality of published studies, using five major criteria.

Results: Twenty-four studies were included in the analysis. The quality of the included studies was poor (31%) or moderate (37%). There was a longitudinal increase in quality of the studies and percentage of prevention. Multivariable linear regression showed that the quality of the study was the only independent predictor of the prevention rate reported in the study.

Conclusions: The results show undertreatment of CIOP might be due to insufficient quality of the studies rather than poor practice or failure to recognise the right patients. Future interventions should comply with five major quality criteria, and a multifaceted approach is required in order to make an impact on the underprescribing of CIOP prophylaxis.
DOI http://dx.doi.org/10.1007/s00198-008-0598-y   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Mon, 11 May 2009, 12:24:22 CST by Sarena Wegener