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The application of toxins and venoms to cardiovascular drug discovery

Hodgson, WC and Isbister, GK (2009). The application of toxins and venoms to cardiovascular drug discovery. Current Opinion in Pharmacology,9(2):173-176.

Document type: Journal Article
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Title The application of toxins and venoms to cardiovascular drug discovery
Author Hodgson, WC
Isbister, GK
Journal Name Current Opinion in Pharmacology
Publication Date 2009
Volume Number 9
Issue Number 2
ISSN 1471-4892   (check CDU catalogue open catalogue search in new window)
Start Page 173
End Page 176
Total Pages 4
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DEST)
Abstract Animal venoms contain a variety of highly selective and potent toxins, which have evolved over thousands/millions of years, which target vital physiological processes. As such, they have proven to be an excellent source of lead compounds for the development of therapeutic agents. In particular, a number of these venom components (e.g. bradykinin-potentiating peptides, sarafotoxins, natriuretic peptides) have profound effects on the cardiovascular system. This review article examines recent progress in the search for lead compounds or novel scaffolds for cardiovascular drug development from animal venoms.
DOI http://dx.doi.org/10.1016/j.coph.2008.11.007   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Thu, 18 Feb 2010, 16:15:26 CST