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Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia

Smith-Vaughan, Heidi C., Marsh, Robyn L., Mackenzie, Grant A., Fisher, Janelle, Morris, Peter S., Hare, Kim M., McCallum, Gabrielle B., Binks, Michael J., Murphy, D., Lum, G., Cook, H., Krause, V., Jacups, Susan P. and Leach, Amanda J. (2009). Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia. Clinical and Vaccine Immunology,16(2):218-221.

Document type: Journal Article
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IRMA ID 10014xPUB11
Title Age-specific cluster of cases of serotype 1 Streptococcus pneumoniae carriage in remote Indigenous communities in Australia
Author Smith-Vaughan, Heidi C.
Marsh, Robyn L.
Mackenzie, Grant A.
Fisher, Janelle
Morris, Peter S.
Hare, Kim M.
McCallum, Gabrielle B.
Binks, Michael J.
Murphy, D.
Lum, G.
Cook, H.
Krause, V.
Jacups, Susan P.
Leach, Amanda J.
Journal Name Clinical and Vaccine Immunology
Publication Date 2009
Volume Number 16
Issue Number 2
ISSN 1556-679X   (check CDU catalogue open catalogue search in new window)
Start Page 218
End Page 221
Total Pages 4
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated.
Keywords Streptococcus pneumoniae
remote
Indigenous communities
DOI http://dx.doi.org/10.1128/CVI.00283-08   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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