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Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal

Isbister, GK and Duffull, SB (2009). Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. International Clinical Psychopharmacology,24(4):174-180.

Document type: Journal Article
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Title Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal
Author Isbister, GK
Duffull, SB
Journal Name International Clinical Psychopharmacology
Publication Date 2009
Volume Number 24
Issue Number 4
ISSN 0268-1315   (check CDU catalogue open catalogue search in new window)
Start Page 174
End Page 180
Total Pages 7
Place of Publication US
Publisher Lippincott Williams & Wilkins
HERDC Category C1 - Journal Article (DEST)
Abstract To investigate factors that predict the probability and duration of mechanical ventilation in quetiapine overdose, and if cardiac toxicity occurs, this cohort study involved 176 patients presenting to a toxicology unit on 286 occasions with quetiapine overdose. Patient demographics, dose, coingestants, single dose activated charcoal (SDAC) administration, requirement for and duration of mechanical ventilation and electrocardiogram parameters (heart rate, QT, QRS) were obtained. A fully Bayesian approach using logistic regression and time-to-event analysis was undertaken to investigate the relationship between predictor variables and the requirement for and duration of intubation. QT versus heart rate was plotted on a QT nomogram to investigate QT prolongation. The commonest clinical effects were central nervous system depression on 136 occasions (48%) and tachycardia (67%). There were no malignant arrhythmias and an abnormal QT occurred in only 24 admissions (8.4%), all with tachycardia. Hypotension (systolic blood pressure
DOI http://dx.doi.org/10.1097/YIC.0b013e32832bb078   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 24 Feb 2010, 05:17:15 CST by Sarena Wegener