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Lack of diagnostic accuracy of the monoclonal stool antigen test for detection of helicobacter pylori infection in young Australian aboriginal children

Ritchie, B., Brewster, D., Tran, C., McNeil, Yvette, Zacharakis, B., Davidson, G. and Butler, R. (2009). Lack of diagnostic accuracy of the monoclonal stool antigen test for detection of helicobacter pylori infection in young Australian aboriginal children. Pediatric Infectious Disease Journal,28(4):287-289.

Document type: Journal Article

IRMA ID 10221xPUB6
Title Lack of diagnostic accuracy of the monoclonal stool antigen test for detection of helicobacter pylori infection in young Australian aboriginal children
Author Ritchie, B.
Brewster, D.
Tran, C.
McNeil, Yvette
Zacharakis, B.
Davidson, G.
Butler, R.
Journal Name Pediatric Infectious Disease Journal
Publication Date 2009
Volume Number 28
Issue Number 4
ISSN 0891-3668   (check CDU catalogue open catalogue search in new window)
Start Page 287
End Page 289
Total Pages 3
Place of Publication US
Publisher Lippincott Williams & Wilkins
HERDC Category C1 - Journal Article (DEST)
Abstract BACKGROUND:: The prevalence of Helicobacter pylori infection among Aboriginal Australians children is unclear. The aims of the present study are to determine the prevalence of H. pylori infection among young Aboriginal children recovering from acute diarrheal disease in hospital and to evaluate the H. pylori stool antigen test as a noninvasive diagnostic test in this setting. METHODS:: This was a prospective comparative study using the C-Urea Breath Test as reference standard. Fifty-two children between 4 months and 2 years of age were consecutively enrolled. These children comprised a representative sample of Australian Aboriginal children admitted to hospital with acute diarrheal disease from remote and rural communities across Northern Territory of Australia. RESULTS:: The overall prevalence of H. pylori was 44.2%. The stool antigen test had a sensitivity of 0.55 (95% confidence interval [CI]: 0.35-0.73) with a positive predictive value of 0.65 (95% CI: 0.42-0.82). The specificity was 0.68 (95% CI: 0.46-0.84) with a negative predictive value of 0.58 (95% CI: 0.39-0.75). Analysis of receiver operator characteristic curve yielded an overall accuracy of the stool antigen test of 61% (48%-75%). CONCLUSIONS:: The prevalence of H. pylori infection among very young Aboriginal children from remote and rural communities was high and consistent with early acquisition. The diagnostic accuracy of the stool antigen test to diagnose H. pylori in this setting was poor.
DOI http://dx.doi.org/10.1097/INF.0b013e31818e039b   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Fri, 26 Feb 2010, 01:16:45 CST by Sarena Wegener