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C-Reactive Protein Concentrations Are Very High and More Stable over Time Than the Traditional Vascular Risk Factors Total Cholesterol and Systolic Blood Pressure in an Australian Aboriginal Cohort

Shemesh, T., Rowley, K.G., Jenkins, AJ, Best, JD and O'Dea, Kerin (2009). C-Reactive Protein Concentrations Are Very High and More Stable over Time Than the Traditional Vascular Risk Factors Total Cholesterol and Systolic Blood Pressure in an Australian Aboriginal Cohort. Clinical Chemistry (Washington, DC),55(2):336-341.

Document type: Journal Article

IRMA ID 83393865xPUB21
Title C-Reactive Protein Concentrations Are Very High and More Stable over Time Than the Traditional Vascular Risk Factors Total Cholesterol and Systolic Blood Pressure in an Australian Aboriginal Cohort
Author Shemesh, T.
Rowley, K.G.
Jenkins, AJ
Best, JD
O'Dea, Kerin
Journal Name Clinical Chemistry (Washington, DC)
Publication Date 2009
Volume Number 55
Issue Number 2
ISSN 1530-8561   (check CDU catalogue open catalogue search in new window)
Start Page 336
End Page 341
Total Pages 6
Place of Publication US
Publisher American Association for Clinical Chemistry, Inc.
HERDC Category C1 - Journal Article (DEST)
Abstract BACKGROUND: Stability of circulating high-sensitivity C-reactive protein (hsCRP) concentrations has implications for its utility in assessing cardiovascular disease (CVD) risk. We sought to determine hsCRP reproducibility in an indigenous Australian cohort with a view to use hsCRP as a marker of future CVD in communitybased risk-factor screenings. METHODS: Seventy people living in a community on the northern coast of Australia participated in 2 risk-factor screenings over amedian (interquartile range) follow-up time of 829 (814 –1001) days. hsCRP was measured by high-sensitivity nephelometry. RESULTS: Geometric mean hsCRP concentrations at baseline and follow-up were 4.5 and 5.1 mg/L, respectively (P 0.220), and Pearson product-moment correlation was 0.775. The proportion of people at high CVD risk (hsCRP 3.0 mg/L) at baseline was 67.1% and remained consistently high (68.6%) at follow-up. Linear regression analysis for follow-up hsCRP as a function of baseline hsCRP, sex, and differences in total and regional body fatness showed that baseline hsCRP was the single predictor in the model, accounting for 63.9% of the total variance in follow-up hsCRP (Pmodel 0.001). Prevalence agreement (95% CI) between baseline and follow-up for the hsCRP3.0 mg/L category was 84% (73%–92%) (PMcNemar=not significant), and coefficient was fair (0.64, compared with 0.31 for systolic blood pressure 140 mmHg and 0.43 for total cholesterol 5.5 mmol/L). CONCLUSIONS: hsCRP concentrations remained consistently reproducible over time across a wide concentration range in an Aboriginal cohort. Correlations between concentrations over time were better than for other traditional CVD risk factors. hsCRP concentration has potential as a marker of future CVD risk.
DOI http://dx.doi.org/10.1373/clinchem.2008.115360   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Fri, 26 Feb 2010, 05:30:36 CST by Sarena Wegener