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The pathophysiology of vivax malaria

Anstey, Nicholas M., Russell, B., Yeo, T. and Price, R. (2009). The pathophysiology of vivax malaria. Trends in Parasitology,25(5):220-227.

Document type: Journal Article

IRMA ID 10002xPUB32
Title The pathophysiology of vivax malaria
Author Anstey, Nicholas M.
Russell, B.
Yeo, T.
Price, R.
Journal Name Trends in Parasitology
Publication Date 2009
Volume Number 25
Issue Number 5
ISSN 1471-4922   (check CDU catalogue open catalogue search in new window)
Start Page 220
End Page 227
Total Pages 8
Place of Publication UK
Publisher Elsevier Ltd.
HERDC Category C1 - Journal Article (DEST)
Abstract Long considered a benign infection, Plasmodium vivax is now recognized as a cause of severe and fatal malaria, despite its low parasite biomass, the increased deformability of vivax-infected red blood cells and an apparent paucity of parasite sequestration. Severe anemia is associated with recurrent bouts of hemolysis of predominantly uninfected erythrocytes with increased fragility, and lung injury is associated with inflammatory increases in alveolar-capillary membrane permeability. Although rare, vivax-associated coma challenges our understanding of pathobiology caused by Plasmodium spp. Host and parasite factors contribute to the risk of severe disease, and comorbidities might contribute to vivax mortality. In this review, we discuss potential mechanisms underlying the syndromes of uncomplicated and severe vivax malaria, identifying key areas for future research.
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Created: Fri, 26 Feb 2010, 06:36:30 CST by Sarena Wegener