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The Effect of Decontamination Procedures on the Pharmacokinetics of Venlafaxine in Overdose

Kumar, VVP, Oscarsson, S, Friberg, LE, Isbister, GK, Hackett, LP and Duffull, SB (2009). The Effect of Decontamination Procedures on the Pharmacokinetics of Venlafaxine in Overdose. Clinical Pharmacology & Therapeutics,86(4):403-410.

Document type: Journal Article
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Title The Effect of Decontamination Procedures on the Pharmacokinetics of Venlafaxine in Overdose
Author Kumar, VVP
Oscarsson, S
Friberg, LE
Isbister, GK
Hackett, LP
Duffull, SB
Journal Name Clinical Pharmacology & Therapeutics
Publication Date 2009
Volume Number 86
Issue Number 4
ISSN 1532-6535   (check CDU catalogue open catalogue search in new window)
Start Page 403
End Page 410
Total Pages 8
Place of Publication US
Publisher Nature Publishing Group
HERDC Category C1 - Journal Article (DEST)
Abstract The aim of this work was to investigate the pharmacokinetics (PK) of venlafaxine in overdose and the effects of single-dose activated charcoal (SDAC) and whole-bowel irrigation (WBI), alone or in combination, as methods of decontamination. The data included 339 concentration–time points from 76 venlafaxine overdose events (median dose 2,625 (150–13,500 mg)); 69 were slow-release doses. SDAC, WBI, a combination of both, or no decontamination were administered to patients as decided by the treating clinician. The data were modeled using WinBUGS (Windows Bayesian Inference Using Gibbs Sampling). A one-compartment model with first-order input and elimination provided an adequate description of the data. SDAC increased clearance (CL) of venlafaxine by 35%, and SDAC and WBI combined reduced the fraction absorbed by 29%. However, the latter produced a greater reduction in maximum plasma concentration (Cmax) for a similar drop in area under the plasma concentration–time curve (AUC). Both SDAC alone, and a combination of SDAC and WBI, decreased the AUC after venlafaxine overdose, but the combination may be more beneficial because it reduces peak concentrations to a greater extent.
Keywords decontamination
procedures
pharmacokinetics
Venlafaxine
overdose
DOI http://dx.doi.org/10.1038/clpt.2009.114   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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