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Electrocardiogram changes and arrhythmias in venlafaxine overdose

Isbister, GK (2009). Electrocardiogram changes and arrhythmias in venlafaxine overdose. British Journal of Clinical Pharmacology,67(5):572-576.

Document type: Journal Article
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Title Electrocardiogram changes and arrhythmias in venlafaxine overdose
Author Isbister, GK
Journal Name British Journal of Clinical Pharmacology
Publication Date 2009
Volume Number 67
Issue Number 5
ISSN 1365-2125   (check CDU catalogue open catalogue search in new window)
Start Page 572
End Page 576
Total Pages 5
Place of Publication UK
Publisher Wiley-Blackwell Publishing Ltd.
HERDC Category C1 - Journal Article (DEST)
Abstract AIMS: To investigate serial electrocardiogram (ECG) parameters, haemodynamic changes and arrhythmias following venlafaxine overdose. METHODS: The study included 369 venlafaxine overdoses in 273 patients presenting to a toxicology unit where an ECG was available. Demographic information, details of ingestion, haemodynamic effects [heart rate and blood pressure (BP)] and complications (arrhythmias and conduction defects) were obtained. ECG parameters (QT, QRS) were measured manually and analysed by visual inspection, including plotting QT-HR pairs on a QT nomogram. RESULTS: The median ingested dose was 1500 mg [interquartile range (IQR) 600-3000 mg; range 75-13 500 mg). Tachycardia occurred in 54% and mild hypertension (systolic BP >140 mmHg) in 40%. Severe hypertension (systolic BP >180 mmHg) and hypotension (systolic BP
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Created: Tue, 02 Mar 2010, 20:27:53 CST by Sarena Wegener