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Some of the people, some of the time: Susceptibility to acute rheumatic fever

Bryant, Penelope A., Robins-Browne, Roy, Carapetis, Jonathan R. and Curtis, Nigel (2009). Some of the people, some of the time: Susceptibility to acute rheumatic fever. Circulation,119(5):742-753.

Document type: Journal Article
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IRMA ID 10414xPUB45
Title Some of the people, some of the time: Susceptibility to acute rheumatic fever
Author Bryant, Penelope A.
Robins-Browne, Roy
Carapetis, Jonathan R.
Curtis, Nigel
Journal Name Circulation
Publication Date 2009
Volume Number 119
Issue Number 5
ISSN 1524-4539   (check CDU catalogue open catalogue search in new window)
Start Page 742
End Page 753
Total Pages 12
Place of Publication United States
Publisher Lippincott Williams & Wilkins
HERDC Category C1 - Journal Article (DEST)
Abstract Acute rheumatic fever is a major cause of heart disease in large parts of the world, but it remains unknown why only a small fraction of those who are infected with rheumatogenic group A streptococci develop an abnormal immune response that leads to acute rheumatic fever. An understanding of the mechanisms underlying host susceptibility can provide important insights into pathogenesis that in turn can inform new treatments. Extensive searches for susceptibility factors have been undertaken, including human leukocyte antigens, B-cell alloantigens, and cytokine genes. Although significant associations have been found between genetic factors and acute rheumatic fever, study results often conflict with each other. This review explores current understanding about host susceptibility to acute rheumatic fever and provides an overall perspective to the number of studies that have recently addressed this subject.
Keywords antigens
genetics
immunology
rheumatic heart disease
susceptibility
DOI http://dx.doi.org/10.1161/CIRCULATIONAHA.108.792135   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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