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Cost-effectiveness of artesunate for the treatment of severe malaria

Lubell, Y., Yeung, S., Dondorp, Arjen M., Day, Nicholas P. J., Nosten, F., Tjitra, Emiliana, Abulfaiz, M., Yunus, E. Bin, Anstey, Nicholas M., Mishra, S. K., Mohanty, S., White, Nicholas J. and Mills, A. J. (2009). Cost-effectiveness of artesunate for the treatment of severe malaria. Tropical Medicine and International Health,14(3):332-337.

Document type: Journal Article

IRMA ID 75039815xPUB62
Title Cost-effectiveness of artesunate for the treatment of severe malaria
Author Lubell, Y.
Yeung, S.
Dondorp, Arjen M.
Day, Nicholas P. J.
Nosten, F.
Tjitra, Emiliana
Abulfaiz, M.
Yunus, E. Bin
Anstey, Nicholas M.
Mishra, S. K.
Mohanty, S.
White, Nicholas J.
Mills, A. J.
Journal Name Tropical Medicine and International Health
Publication Date 2009
Volume Number 14
Issue Number 3
ISSN 1365-3156   (check CDU catalogue  open catalogue search in new window)
Start Page 332
End Page 337
Total Pages 6
Place of Publication UK
Publisher Wiley-Blackwell Publishing Ltd.
HERDC Category C1 - Journal Article (DEST)
Abstract Objective  To explore the cost-effectiveness of artesunate against quinine based principally on the findings of a large multi-centre trial carried out in Southeast Asia.

Methods
  Trial data were used to compare mortality of patients with severe malaria, treated with either artesunate or quinine. This was combined with retrospectively collected cost data to estimate the incremental cost per death averted with the use of artesunate instead of quinine.

Results  The incremental cost per death averted using artesunate was approximately 140 USD. Artesunate maintained this high level of cost-effectiveness also when allowing for the uncertainty surrounding the cost and effectiveness assessments.

Conclusion  This analysis confirms the vast superiority of artesunate for treatment of severe malaria from an economic as well as a clinical perspective.
DOI http://dx.doi.org/10.1111/j.1365-3156.2009.02227.x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 03 Mar 2010, 19:28:13 CST by Sarena Wegener