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Primary ocular melioidosis due to a single genotype of Burkholderia pseudomallei in two cats from Arnhem Land in the Northern Territory of Australia

Parkes, Helen M., Shilton, Catherine M., Jerrett, Ian V., Benedict, Suresh, Spratt, Brian G., Godoy, Daniel, O'Brien, Carolyn R., Krockenberger, Mark B., Mayo, Mark J., Currie, Bart J. and Malik, Richard (2009). Primary ocular melioidosis due to a single genotype of Burkholderia pseudomallei in two cats from Arnhem Land in the Northern Territory of Australia. Journal of Feline Medicine and Surgery,11(10):856-863.

Document type: Journal Article

IRMA ID 10103xPUB15
Title Primary ocular melioidosis due to a single genotype of Burkholderia pseudomallei in two cats from Arnhem Land in the Northern Territory of Australia
Author Parkes, Helen M.
Shilton, Catherine M.
Jerrett, Ian V.
Benedict, Suresh
Spratt, Brian G.
Godoy, Daniel
O'Brien, Carolyn R.
Krockenberger, Mark B.
Mayo, Mark J.
Currie, Bart J.
Malik, Richard
Journal Name Journal of Feline Medicine and Surgery
Publication Date 2009
Volume Number 11
Issue Number 10
ISSN 1532-2750   (check CDU catalogue open catalogue search in new window)
Start Page 856
End Page 863
Total Pages 8
Place of Publication UK
Publisher Elsevier Ltd
HERDC Category C3 - Journal Article - Non-refereed articles (including articles in professional journals) (internal)
Abstract Melioidosis was diagnosed in two domestic crossbred cats presented for unilateral ocular disease. One patient was born and bred in Nhulunbuy, Arnhem Land, while the other had moved there 6 months previously from Townsville, Queensland. Both patients were presented with sudden onset of a ‘red eye’ and blepharospasm, which progressed to an enlarged, painful, firm globe with loss of pupillary light reflexes and vision. An obvious primary focus of infection outside the eye was not detected in either cat. In both patients, the affected eye was surgically removed and vitreal culture revealed a pure growth of Burkholderia pseudomallei. In each instance, the infection had penetrated the sclera to produce retrobulbar cellulitis, and in one case frank retrobulbar abscessation. Histologically, there was a pyogranulomatous uveitis with extensive destruction of intraocular structures. The first case was still alive approximately 1 year following enucleation and limited antimicrobial therapy using amoxicillin clavulanate and doxycycline. The second was euthanased when a localised abscess developed on the same side of the face as the healed surgical incision, despite appropriate antimicrobial therapy. Both cases were caused by the same multilocus sequence type of B pseudomallei (ST 116), which had only been isolated previously from two human patients, both living in the same isolated geographical area as the cats of this report. Apart from the geographical clustering, no epidemiological links were evident between the two cats and/or the two people. The presumptive pathogenesis of these infections is discussed in relation to current knowledge about melioidosis in northern Australia.
DOI http://dx.doi.org/10.1016/j.jfms.2009.02.009   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 03 Mar 2010, 20:23:32 CST by Sarena Wegener