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Relationships between birthweight and biomarkers of chronic disease in childhood: Aboriginal birth cohort study 1987-2001

Sayers, Susan, Singh, Gurmeet, Mott, S., McDonnell, Joseph and Hoy, W. (2009). Relationships between birthweight and biomarkers of chronic disease in childhood: Aboriginal birth cohort study 1987-2001. Paediatric and Perinatal Epidemiology,23(6):548-556.

Document type: Journal Article

IRMA ID M00002xPUB12
Title Relationships between birthweight and biomarkers of chronic disease in childhood: Aboriginal birth cohort study 1987-2001
Author Sayers, Susan
Singh, Gurmeet
Mott, S.
McDonnell, Joseph
Hoy, W.
Journal Name Paediatric and Perinatal Epidemiology
Publication Date 2009
Volume Number 23
Issue Number 6
ISSN 0269-5022   (check CDU catalogue open catalogue search in new window)
Start Page 548
End Page 556
Total Pages 9
Place of Publication UK
Publisher Wiley-Blackwell Publishing
HERDC Category C1 - Journal Article (DEST)
Abstract Reports of relationships between lower birthweight and later chronic diseases are mainly from populations with low rates of low birthweight (LBW) and growth-restricted births. A prospective study of an Australian Aboriginal birth cohort with a mean birthweight of 3050 g (SD 630), 16% LBW and 28% fetal growth restriction was used to examine the relationships between birthweight and selected biomarkers of chronic adult disease. At a mean age of 11.4 years (range 8.9–14), the mean weight was 35.7 kg (SD 11.8) and the mean height was 143.8 cm (SD 10.6). Using the Centers for Disease Control and Prevention (CDC) 2000 growth references, weight and height-for-age z-scores were −0.8 (SD 1.4) and −0.5 (SD 1.07) respectively and using World Health Organisation criteria, 19% of children were classified as underweight (weight for age Z-score <2.0). The relationships between birthweight and blood pressure (n = 475), total cholesterol (n = 461), Apolipoprotein A-1 (n = 343), Apolipoprotein B (n = 390), respiratory function tests (n = 427), kidney size determined by ultrasound (n = 446), urinary albumin/creatinine ratio (n = 420) and fasting triglycerides (n = 281), insulin (n = 272) and glucose (n = 279) were examined using regression models adjusted for sex, gestational age, current age and puberty status. In this population with high rates of fetal growth restriction at birth and an excess of under-nutrition at age 11 years we found that birthweight had a negative relationship with child blood pressure only, while current child weight was positively related to blood pressure, total cholesterol, Apolipoprotein B, respiratory function tests, kidney size, and fasting triglycerides, insulin and glucose.
Keywords birthweight
childhood weight
glucose
blood pressure
lipids
kidney size
lung function
birth cohort
DOI http://dx.doi.org/10.1111/j.1365-3016.2009.01071.x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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