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Heroes or villains? T regulatory cells in malaria infection

Scholzen, A., Minigo, Gabriela and Plebanski, M. (2010). Heroes or villains? T regulatory cells in malaria infection. Trends in Parasitology,26(1):16-25.

Document type: Journal Article

IRMA ID 10728xPUB11
Title Heroes or villains? T regulatory cells in malaria infection
Author Scholzen, A.
Minigo, Gabriela
Plebanski, M.
Journal Name Trends in Parasitology
Publication Date 2010
Volume Number 26
Issue Number 1
ISSN 1471-4922   (check CDU catalogue open catalogue search in new window)
Start Page 16
End Page 25
Total Pages 10
Place of Publication UK
Publisher Elsevier Ltd.
HERDC Category C1 - Journal Article (DEST)
Abstract Infection with Plasmodium parasites can cause severe disease due to a lack of protective immune responses to clear parasitemia, or to the host's inability to control excessive inflammation resulting in immunopathology. T regulatory cells (Tregs), key mediators of immune homeostasis, are increased in number and modulate disease in human and murine malaria. Several recent studies provide new insights into the mechanisms and functional consequences of Treg induction by P. falciparum. This review integrates and discusses the findings published on Tregs in human and murine malaria to date, with emphasis on Treg induction (host components, kinetics and parasite-dependence) and their diverse roles (protective or pathological) during infection.
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Created: Mon, 22 Mar 2010, 12:41:29 CST by Sarena Wegener