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emm and C-repeat region molecular typing of Beta-Hemolytic Streptococci in a tropical country: implications for vaccine Development

Steer, Andrew C., Magor, Graham, Jenney, Adam W., Kado, Jospeh, Good, Michael F., McMillian, David, Batzloff, Michael and Carapetis, Jonathan R. (2009). emm and C-repeat region molecular typing of Beta-Hemolytic Streptococci in a tropical country: implications for vaccine Development. Journal of Clinical Microbiology,47(8):2502-2509.

Document type: Journal Article
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IRMA ID 10414xPUB41
Title emm and C-repeat region molecular typing of Beta-Hemolytic Streptococci in a tropical country: implications for vaccine Development
Author Steer, Andrew C.
Magor, Graham
Jenney, Adam W.
Kado, Jospeh
Good, Michael F.
McMillian, David
Batzloff, Michael
Carapetis, Jonathan R.
Journal Name Journal of Clinical Microbiology
Publication Date 2009
Volume Number 47
Issue Number 8
ISSN 1098-660X   (check CDU catalogue  open catalogue search in new window)
Start Page 2502
End Page 2509
Total Pages 8
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DEST)
Abstract We designed a study to investigate the molecular epidemiology of group A streptococcal (GAS) and group C and G streptococcal (GCS and GGS) disease in Fiji, a country which is known to have a high burden of streptococcal disease. Molecular typing of the N-terminal portion (emm typing) of the M protein was performed with 817 isolates (535 GAS and 282 GCS/GGS). We also performed genotyping of the C-repeat region in 769 of these isolates to identify J14 sequence types. The profile of emm types for Fiji was very different from that found for the United States and Europe. There were no dominant emm types and a large number of overlapping types among clinical disease states. Commonly found GAS emm types in industrialized countries, including emm1, emm12, and emm28, were not found among GAS isolates from Fiji. Over 93% of GAS isolates and over 99% of GCS/GGS isolates that underwent J14 sequence typing contained either J14.0 or J14.1. Our data have implications for GAS vaccine development in developing countries and suggest that a vaccine based upon the conserved region of the M protein may be a feasible option for Fiji and potentially for other tropical developing countries.
DOI http://dx.doi.org/10.1128/JCM.00312-09   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
Additional Notes Copyright by the American Society for Microbiology


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