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Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine

Russell, F. M., Balloch, A., Tang, M. L. K., Carapetis, Jonathan R., Licciardi, Paul V., Nelson, J., Jenney, A. W. J., Tikoduadua, L., Waqatakirewa, L., Pryor, J., Byrnes, G. B., Cheung, Y. B. and Mulholland, E. Kim (2009). Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine. Vaccine,27(41):5685-5691.

Document type: Journal Article

IRMA ID 75039815xPUB113
Title Immunogenicity following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine
Author Russell, F. M.
Balloch, A.
Tang, M. L. K.
Carapetis, Jonathan R.
Licciardi, Paul V.
Nelson, J.
Jenney, A. W. J.
Tikoduadua, L.
Waqatakirewa, L.
Pryor, J.
Byrnes, G. B.
Cheung, Y. B.
Mulholland, E. Kim
Journal Name Vaccine
Publication Date 2009
Volume Number 27
Issue Number 41
ISSN 0264-410X   (check CDU catalogue open catalogue search in new window)
Start Page 5685
End Page 5691
Total Pages 7
Place of Publication United Kingdom
Publisher Elsevier Ltd
HERDC Category C1 - Journal Article (DEST)
Abstract The aim was to identify an appropriate infant pneumococcal vaccination strategy for resource poor countries. Fijian infants received zero, one, two, or three doses of 7-valent pneumococcal conjugate vaccine (PCV) in early infancy. Following three PCV doses, geometric mean concentration (GMC) to all seven serotypes were ≥1.0 μg/mL, and >85% of children achieved antibody levels ≥0.35 μg/mL at 18 weeks. Following two doses, GMC were lower for 6B, 14, and 23F, but higher for 19F compared with three doses. Following a single dose, significant responses were seen for all serotypes post-primary series compared with the unvaccinated. By 12 months, differences between two and three doses persisted for serotype 14 only. Although GMC following three doses are higher than after two doses, the differences were small. A single dose may offer some protection for most serotypes.
Keywords Pneumococcal conjugate vaccine
DOI http://dx.doi.org/10.1016/j.vaccine.2009.06.098   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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