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A Comprehensive Model for the Humoral Coagulation Network in Humans

Wajima, T, Isbister, GK and Duffull, SB (2009). A Comprehensive Model for the Humoral Coagulation Network in Humans. Clinical Pharmacology and Therapeutics,86(3):290-298.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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ISI LOC 000269549100018
Title A Comprehensive Model for the Humoral Coagulation Network in Humans
Author Wajima, T
Isbister, GK
Duffull, SB
Journal Name Clinical Pharmacology and Therapeutics
Publication Date 2009
Volume Number 86
Issue Number 3
ISSN 1532-6535   (check CDU catalogue open catalogue search in new window)
Start Page 290
End Page 298
Total Pages 9
Place of Publication US
Publisher Nature Publishing Group
HERDC Category C1 - Journal Article (DEST)
Abstract Coagulation is an important process in hemostasis and comprises a complicated interaction of multiple enzymes and proteins. We have developed a mechanistic quantitative model of the coagulation network. The model accurately describes the time courses of coagulation factors following in vivo activation as well as in vitro blood coagulation tests of prothrombin time (PT, often reported as international normalized ratio (INR)) and activated partial thromboplastin time (aPTT). The model predicts the concentration–time and time–effect profiles of warfarin, heparins, and vitamin K in humans. The model can be applied to predict the time courses of coagulation kinetics in clinical situations (e.g., hemophilia) and for biomarker identification during drug development. The model developed in this study is the first quantitative description of the comprehensive coagulation network.
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Created: Mon, 29 Mar 2010, 21:05:38 CST