Charles Darwin University

CDU eSpace
Institutional Repository

 
CDU Staff and Student only
 

A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom

Isbister, GK, O'Leary, M, Miller, M, Brown, SGA, Ramasamy, S, James, R and Schneider, JS (2008). A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom. British Journal of Clinical Pharmacology,65(1):139-143.

Document type: Journal Article
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Altmetric Score Altmetric Score is 4
Google Scholar Search Google Scholar

ISI LOC 000251667200017
Title A comparison of serum antivenom concentrations after intravenous and intramuscular administration of redback (widow) spider antivenom
Author Isbister, GK
O'Leary, M
Miller, M
Brown, SGA
Ramasamy, S
James, R
Schneider, JS
Journal Name British Journal of Clinical Pharmacology
Publication Date 2008
Volume Number 65
Issue Number 1
ISSN 0306-5251   (check CDU catalogue open catalogue search in new window)
Start Page 139
End Page 143
Total Pages 5
Place of Publication United Kingdom
Publisher Blackwell Publishing Ltd
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract AIMS There are no studies measuring antivenom concentrations following intramuscular administration. This study aimed to compare antivenom concentrations following intravenous and intramuscular administration of redback spider antivenom (RBSAV). METHODS Twenty patients recruited to a controlled trial comparing intramuscular and intravenous administration of antivenom had serial blood samples collected at 30 min intervals for 2 h after the administration of one or two doses of antivenom. Antivenom concentration was measured using an enzyme immunoassay. RESULTS Ten patients received intramuscular antivenom but antivenom could not be detected in serum after either one or two vials, at any time point. The median time of the final sample after commencement of antivenom treatment in these patients was 3.2 h (1.8–5 h). Ten patients received intravenous antivenom (three one vial and seven two or more vials) and antivenom was detected in all patients. CONCLUSIONS RBS AV given by the intramuscular route is unlikely to be effective in the treatment of redback (widow) spider bite.
DOI http://dx.doi.org/10.1111/j.1365-2125.2007.03004.x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
Versions
Version Filter Type
Access Statistics: 145 Abstract Views  -  Detailed Statistics
Created: Tue, 30 Mar 2010, 21:22:51 CST