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A model for venom-induced consumptive coagulopathy in snake bite

Tanos, PP, Isbister, GK, Lalloo, DG, Kirkpatrick, CMJ and Duffull, SB (2008). A model for venom-induced consumptive coagulopathy in snake bite. Toxicon,52(7):769-780.

Document type: Journal Article
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Title A model for venom-induced consumptive coagulopathy in snake bite
Author Tanos, PP
Isbister, GK
Lalloo, DG
Kirkpatrick, CMJ
Duffull, SB
Journal Name Toxicon
Publication Date 2008
Volume Number 52
Issue Number 7
ISSN 0041-0101   (check CDU catalogue open catalogue search in new window)
Start Page 769
End Page 780
Total Pages 12
Place of Publication UK
Publisher Pergamon
Field of Research 1115 - Pharmacology and Pharmaceutical Sciences
HERDC Category C1 - Journal Article (DEST)
Abstract Many snake venoms contain procoagulant toxins that activate the coagulation cascade and cause venom-induced consumptive coagulopathy (VICC). We developed a semi-mechanistic model of the clotting cascade in order to explore the effects of the procoagulant toxin from taipan venom on this system as well as the effects of antivenom. Simulations of the time course in the change of clotting factors were compared to data collected from taipan envenomed patients. The model accurately predicted the observed concentration of clotting factors over time following taipan envenomation. Investigations from the model indicated that the upper limit of the half-life of the procoagulant toxin was 1 h. Simulations from the model also suggest that antivenom for Australasian elapids has negligible effect on reducing the recovery time of the coagulation profile unless administered almost immediately after envenomation. The model has generality to be expanded to describe the effects of other venoms and drugs on the clotting cascade.
DOI http://dx.doi.org/10.1016/j.toxicon.2008.08.013   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Wed, 31 Mar 2010, 21:05:33 CST by Sarena Wegener