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Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth disease

Isbister, GK, Burns, J, Prior, F and Ouvrier, RA (2008). Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth disease. Journal of the Neurological Sciences,268(1-2):160-162.

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Title Safety of nitrous oxide administration in patients with Charcot-Marie-Tooth disease
Author Isbister, GK
Burns, J
Prior, F
Ouvrier, RA
Journal Name Journal of the Neurological Sciences
Publication Date 2008
Volume Number 268
Issue Number 1-2
ISSN 0022-510X   (check CDU catalogue open catalogue search in new window)
Start Page 160
End Page 162
Total Pages 3
Place of Publication Netherlands
Publisher Elsevier BV
Field of Research 1103 - Clinical Sciences
1109 - Neurosciences
HERDC Category C1 - Journal Article (DEST)
Abstract Nitrous oxide is routinely administered to children and adults with Charcot-Marie-Tooth disease (CMT) as an anaesthetic for procedures such as nerve conduction studies and maintenance for general anaesthesia. However it is listed as a ‘moderate to significant’ risk of potential toxicity and worsening neuropathy in people with CMT by the CMT Association (USA), CMT Association of Australia, CMT International (Canada) and CMT United Kingdom. We performed a systematic review focussing on the use of nitrous oxide in patients with CMT to help clarify its safety. This identified 11 studies reporting 41 exposures to therapeutically inhaled nitrous oxide as maintenance for general anaesthesia with no reports of adverse effects or worsening of CMT neuropathy. In the absence of a single case in the literature reporting worsening neuropathy in CMT patients receiving nitrous oxide, this review provides good evidence that nitrous oxide should be considered a safe agent for use in children and adults with CMT.
DOI http://dx.doi.org/10.1016/j.jns.2007.12.004   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Mon, 19 Apr 2010, 21:07:07 CST by Sarena Wegener