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Soluble transferrin receptor in Aboriginal children with a high prevalence of iron deficiency and infection

Ritchie, B, McNeil, Y and Brewster, DR (2004). Soluble transferrin receptor in Aboriginal children with a high prevalence of iron deficiency and infection. Tropical Medicine and International Health,9(1):96-105.

Document type: Journal Article
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Title Soluble transferrin receptor in Aboriginal children with a high prevalence of iron deficiency and infection
Author Ritchie, B
McNeil, Y
Brewster, DR
Journal Name Tropical Medicine and International Health
Publication Date 2004
Volume Number 9
Issue Number 1
ISSN 1365-3156   (check CDU catalogue open catalogue search in new window)
Start Page 96
End Page 105
Total Pages 10
Place of Publication UK
Publisher Wiley-Blackwell Publishing Ltd.
Field of Research 1117 - Public Health and Health Services
HERDC Category C1 - Journal Article (DEST)
Abstract Objectives: Aboriginal children in tropical Australia have a high prevalence of both iron deficiency and acute infections, making it difficult to differentiate their relative contributions to anaemia. The aims of this study were to compare soluble transferrin receptor with ferritin in iron deficiency anaemia (IDA), and to examine how best to distinguish the effect of iron deficiency from infection on anaemia. Methods: We conducted a prospective study of 228 admissions to Royal Darwin Hospital in children from 6 to 60 months of age. Transferrin receptor concentrations were measured by a particle-enhanced immunoturbidimetric assay and ferritin by a microparticle enzyme immunoassay. Results: On multiple regression, the best explanatory variables for haemoglobin differences (r2 = 33.7%, P < 0.001) were mean corpuscular volume (MCV), red cell distribution width (RDW) and C-reactive protein (CRP); whereas transferrin receptor and ferritin were not significant (P > 0.4). Using ≥2 abnormal indices (MCV, RDW, blood film) + haemoglobin
DOI http://dx.doi.org/10.1046/j.1365-3156.2003.01158.x   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)
 
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Created: Mon, 19 Apr 2010, 22:10:46 CST by Sarena Wegener