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Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies

Walton, Shelley F., Pizzutto, Susan, Slender, Amy, Viberg, Linda, Holt, Deborah, Hales, Belinda J., Kemp, David J., Currie, Bart J., Rolland, Jennifer M. and O'Hehir, Robyn (2010). Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies. Clinical and Vaccine Immunology,17(9):1428-1438.

Document type: Journal Article
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IRMA ID 81704288xPUB262
Title Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies
Author Walton, Shelley F.
Pizzutto, Susan
Slender, Amy
Viberg, Linda
Holt, Deborah
Hales, Belinda J.
Kemp, David J.
Currie, Bart J.
Rolland, Jennifer M.
O'Hehir, Robyn
Journal Name Clinical and Vaccine Immunology
Publication Date 2010
Volume Number 17
Issue Number 9
ISSN 1556-6811   (check CDU catalogue open catalogue search in new window)
Start Page 1428
End Page 1438
Total Pages 10
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract Scabies, a parasitic skin infestation by the burrowing “itch” mite Sarcoptes scabiei, causes significant health problems for children and adults worldwide. Crusted scabies is a particularly severe form of scabies in which mites multiply into the millions, causing extensive skin crusting. The symptoms and signs of scabies suggest host immunity to the scabies mite, but the specific resistant response in humans remains largely uncharacterized. We used 4 scabies mite recombinant proteins with sequence homology to extensively studied house dust mite allergens to investigate a differential immune response between ordinary scabies and the debilitating crusted form of the disease. Subjects with either disease form showed serum IgE against recombinant S. scabiei cysteine and serine proteases and apolipoprotein, whereas naive subjects showed minimal IgE reactivity. Significantly (P < 0.05) greater serum IgE and IgG4 binding to mite apolipoprotein occurred in subjects with crusted scabies than in those with ordinary scabies. Both subject groups showed strong proliferative responses (peripheral blood mononuclear cells) to the scabies antigens, but the crusted scabies group showed increased secretion of the Th2 cytokines interleukin 5 (IL-5) and IL-13 and decreased Th1 cytokine gamma interferon (IFN-γ) in response to the active cysteine protease. These data confirm that a nonprotective allergic response occurs in the crusted disease form and demonstrate that clinical severity is associated with differences in the type and magnitude of the antibody and cellular responses to scabies proteins. A quantitative IgE inhibition assay identified IgE immunoreactivity of scabies mite antigens distinct from that of house dust mite antigens, which is potentially important for specific scabies diagnosis and therapy.

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