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Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster

Russell, F. M., Carapetis, Jonathan R., Satzke, C., Tikoduadua, L., Waqatakirewa, L., Chandra, R., Seduadua, A., Oftadeh, S., Cheung, Y. B., Gilbert, G. L. and Mulholland, E. Kim (2010). Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster. Clinical and Vaccine Immunology,17(12):1970-1976.

Document type: Journal Article
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IRMA ID 81704288xPUB120
Title Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster
Author Russell, F. M.
Carapetis, Jonathan R.
Satzke, C.
Tikoduadua, L.
Waqatakirewa, L.
Chandra, R.
Seduadua, A.
Oftadeh, S.
Cheung, Y. B.
Gilbert, G. L.
Mulholland, E. Kim
Journal Name Clinical and Vaccine Immunology
Publication Date 2010
Volume Number 17
Issue Number 12
ISSN 1556-6811   (check CDU catalogue open catalogue search in new window)
Start Page 1970
End Page 1976
Total Pages 6
Place of Publication Washington, United States
Publisher American Society for Microbiology
HERDC Category C1 - Journal Article (DIISR)
Abstract This study was conducted to evaluate the effect of a reduced-dose 7-valent pneumococcal conjugate vaccine (PCV) primary series followed by a 23-valent pneumococcal polysaccharide vaccine (23vPPS) booster on nasopharyngeal (NP) pneumococcal carriage. For this purpose, Fijian infants aged 6 weeks were randomized to receive 0, 1, 2, or 3 PCV doses. Within each group, half received 23vPPS at 12 months. NP swabs were taken at 6, 9, 12, and 17 months and were cultured for Streptococcus pneumoniae. Isolates were serotyped by multiplex PCR and a reverse line blot assay. There were no significant differences in PCV vaccine type (VT) carriage between the 3- and 2-dose groups at 12 months. NP VT carriage was significantly higher (P, <0.01) in the unvaccinated group than in the 3-dose group at the age of 9 months. There appeared to be a PCV dose effect in the cumulative proportion of infants carrying the VT, with less VT carriage occurring with more doses of PCV. Non-PCV serotype (NVT) carriage rates were similar for all PCV groups. When groups were pooled by receipt or nonreceipt of 23vPPS at 12 months, there were no differences in pneumococcal, VT, or NVT carriage rates between the 2 groups at the age of 17 months. In conclusion, there appeared to be a PCV dose effect on VT carriage, with less VT carriage occurring with more doses of PCV. By the age of 17 months, NVT carriage rates were similar for all groups. 23vPPS had no impact on carriage, despite the substantial boosts in antibody levels.

DOI http://dx.doi.org/10.1128/CVI.00117-10   (check subscription with CDU E-Gateway service for CDU Staff and Students  check subscription with CDU E-Gateway in new window)


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